IMPORTANT: RECOMMEND TO USE CHROME, FIREFOX AND SAFARI TO AVOID LOSS OF FUNCTIONALITY
Introduction
The human disease network database (DNetDB) is the first disease relationship database from the viewpoint of dysfunctional regulation mechanism which was estimated based on gene expression profiles by using differential coexpression analysis method. It contains 1,326 disease relationships among 108 diseases. DNetDB provides insightful clues to investigate diseases’ etiology and pathogenesis, perform drug repositioning, and design novel therapeutic interventions for researchers and doctors. more
Statistics
Terms No.
Disease network Positive disease relationships 797
Negative disease relationships 529
GEO series 86
Disease-tissue 108
Sample sources 24
Disease-related genes 7,357
Drugs 342
Pathways 5,593
Workflow
We got 108 diseases from 86 GEO series (GSE).more

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For 108 sets (i.e. 108 disease statuses) with disease samples and corresponding health samples,more

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We assigned pathways’ dCs to be the average dC of their component genes.more

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We used the R package, more

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External Link:

Disease Relationship Table